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Structure-activity relationship studies of allylamine type of antimycotics were carried out to evaluate the effect of naphthyl and methyl portion of naftifine. Compounds with 4-fluorophenyl(2a-5a), 2-fluorophenyl(2b-5b), 2,4-dichlorophenyl(2c- 5c), 2,6-dichlorophenyl(2d-5d), 4-nitrophenyl(2e-5e), and 2,3-dihydro-benzo[1,4] dioxan-6-yl(2f-5f) instead of naphthyl group with hydrogen(3a-ef), methyl(4a-4f), and ethyl(5a-5f) in the place of methyl in naftifine were synthesized and tested their in vitro anti-fungal activity against five different fungi. Eight compounds (3a, 5a, 3c, 4c, 4d, 5d, 5e, and 4f) neamine(5e) displayed moderate antifungal activity against all five different fungi.
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